Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
TGCT_ReactomeCoreGenes Exclusive	TGCT_BaileyGenes	7.20e-04	7.20e-04	7.20e-04	7.55e-04
TGCT_BaileyGenes Exclusive	TGCT_ReactomeCoreGenes	3.12e-06	1.75e-05	1.11e-10	9.86e-10
TGCT_ReactomeCoreGenes Exclusive	TGCT_BaileyGenes Exclusive	5.17e-01	5.17e-01	5.17e-01	4.49e-01
TGCT_BaileyGenes Exclusive	TGCT_ReactomeCoreGenes Exclusive	2.42e-05	1.16e-04	8.05e-10	9.67e-08
TGCT_ReactomeCoreGenes Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
TGCT_BaileyGenes Exclusive	Overlap	4.22e-04	9.63e-03	2.96e-04	7.19e-05
Overlap	Exclusives	8.17e-08	7.03e-08	2.07e-16	6.04e-13



Evaluating how well TGCT_ReactomeCoreGenes genes are linked to TGCT_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
TGCT_ReactomeCoreGenes Exclusive	TGCT_BaileyGenes	0.91	0.95	2.65	1.91	3.54
TGCT_BaileyGenes Exclusive	TGCT_ReactomeCoreGenes	0.87	1.88	4.58	1.90	7.04
TGCT_ReactomeCoreGenes Exclusive	TGCT_BaileyGenes Exclusive	0.77	0.19	0.33	0.49	1.30
TGCT_BaileyGenes Exclusive	TGCT_ReactomeCoreGenes Exclusive	0.86	2.11	4.37	1.70	6.32
TGCT_ReactomeCoreGenes Exclusive	Overlap	1.00	1.68	3.68	1.77	3.04
TGCT_BaileyGenes Exclusive	Overlap	0.97	2.88	4.38	1.24	2.74
Overlap	Exclusives	0.91	2.74	6.33	2.97	7.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
TGCT_ReactomeCoreGenes Exclusive	TGCT_BaileyGenes	0.34	230.01	363.51	710.08	1245.03
TGCT_BaileyGenes Exclusive	TGCT_ReactomeCoreGenes	0.01	8.10	20.60	6.33	29.71
TGCT_ReactomeCoreGenes Exclusive	TGCT_BaileyGenes Exclusive	0.05	141.02	207.79	203.00	113.94
TGCT_BaileyGenes Exclusive	TGCT_ReactomeCoreGenes Exclusive	0.01	2.23	22.92	6.98	1.93
TGCT_ReactomeCoreGenes Exclusive	Overlap	0.41	140.14	287.56	641.41	551.66
TGCT_BaileyGenes Exclusive	Overlap	0.00	2.76	5.78	1.47	14.13
Overlap	Exclusives	0.02	7.55	38.35	5.55	21.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
TGCT_ReactomeCoreGenes Exclusive	25	25	
TGCT_BaileyGenes Exclusive	2	2	
Overlap	3	3