Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
THCA_ReactomeCoreGenes Exclusive	THCA_BaileyGenes	5.42e-02	5.82e-01	3.18e-04	2.35e-04
THCA_BaileyGenes Exclusive	THCA_ReactomeCoreGenes	4.32e-01	2.77e-01	1.16e-06	5.56e-06
THCA_ReactomeCoreGenes Exclusive	THCA_BaileyGenes Exclusive	1.66e-01	4.83e-01	2.76e-03	2.11e-03
THCA_BaileyGenes Exclusive	THCA_ReactomeCoreGenes Exclusive	7.27e-01	2.38e-01	5.44e-06	1.87e-05
THCA_ReactomeCoreGenes Exclusive	Overlap	3.96e-02	1.98e-02	1.98e-02	7.92e-02
THCA_BaileyGenes Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	9.10e-01	1.33e-02	1.28e-16	3.34e-09



Evaluating how well THCA_ReactomeCoreGenes genes are linked to THCA_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
THCA_ReactomeCoreGenes Exclusive	THCA_BaileyGenes	0.87	0.51	1.20	2.22	3.92
THCA_BaileyGenes Exclusive	THCA_ReactomeCoreGenes	0.80	0.43	2.46	1.45	4.82
THCA_ReactomeCoreGenes Exclusive	THCA_BaileyGenes Exclusive	0.85	0.34	1.22	1.73	3.21
THCA_BaileyGenes Exclusive	THCA_ReactomeCoreGenes Exclusive	0.79	0.39	2.17	1.49	4.76
THCA_ReactomeCoreGenes Exclusive	Overlap	0.97	0.80	10955961826420.00	1.32	1.79
THCA_BaileyGenes Exclusive	Overlap	0.99	0.91	inf	2.17	1.62
Overlap	Exclusives	0.82	284882736938625.00	3.53	1.79	6.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
THCA_ReactomeCoreGenes Exclusive	THCA_BaileyGenes	0.00	0.15	0.56	3.87	10.53
THCA_BaileyGenes Exclusive	THCA_ReactomeCoreGenes	0.01	-0.00	6.15	2.47	12.50
THCA_ReactomeCoreGenes Exclusive	THCA_BaileyGenes Exclusive	0.00	0.06	0.31	2.50	2.08
THCA_BaileyGenes Exclusive	THCA_ReactomeCoreGenes Exclusive	0.00	-0.16	4.56	3.40	0.71
THCA_ReactomeCoreGenes Exclusive	Overlap	0.00	0.09	335899520930583.00	1.96	-0.05
THCA_BaileyGenes Exclusive	Overlap	0.00	1.36	13700259415898778.00	9.24	1.83
Overlap	Exclusives	0.01	2068399288831046.00	5.96	1.21	11.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
THCA_ReactomeCoreGenes Exclusive	23	23	
THCA_BaileyGenes Exclusive	8	8	
Overlap	1	1