Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UCS_ReactomeCoreGenes Exclusive	UCS_BaileyGenes	1.54e-03	6.48e-03	3.84e-08	1.00e-08
UCS_BaileyGenes Exclusive	UCS_ReactomeCoreGenes	7.20e-04	3.17e-02	1.16e-07	1.94e-05
UCS_ReactomeCoreGenes Exclusive	UCS_BaileyGenes Exclusive	1.96e-02	8.48e-03	4.19e-07	4.02e-07
UCS_BaileyGenes Exclusive	UCS_ReactomeCoreGenes Exclusive	8.22e-02	3.98e-01	1.59e-04	7.72e-04
UCS_ReactomeCoreGenes Exclusive	Overlap	9.85e-05	9.85e-05	5.91e-04	9.85e-04
UCS_BaileyGenes Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.96e-04
Overlap	Exclusives	6.09e-04	9.26e-06	6.68e-10	6.07e-10



Evaluating how well UCS_ReactomeCoreGenes genes are linked to UCS_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UCS_ReactomeCoreGenes Exclusive	UCS_BaileyGenes	0.91	1.01	3.67	2.05	5.63
UCS_BaileyGenes Exclusive	UCS_ReactomeCoreGenes	0.98	1.35	2.33	2.74	3.52
UCS_ReactomeCoreGenes Exclusive	UCS_BaileyGenes Exclusive	0.90	0.69	3.22	1.69	4.68
UCS_BaileyGenes Exclusive	UCS_ReactomeCoreGenes Exclusive	0.97	0.93	1.65	2.35	2.71
UCS_ReactomeCoreGenes Exclusive	Overlap	0.99	3.23	2.24	1.56	2.75
UCS_BaileyGenes Exclusive	Overlap	1.00	1.82	1.46	2.57	2.77
Overlap	Exclusives	0.92	1.95	4.96	1.92	5.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UCS_ReactomeCoreGenes Exclusive	UCS_BaileyGenes	0.01	1.83	5.44	4.83	4.02
UCS_BaileyGenes Exclusive	UCS_ReactomeCoreGenes	0.01	4.99	9.17	20.26	22.41
UCS_ReactomeCoreGenes Exclusive	UCS_BaileyGenes Exclusive	0.00	0.53	2.72	2.71	1.96
UCS_BaileyGenes Exclusive	UCS_ReactomeCoreGenes Exclusive	0.00	0.78	2.39	7.45	12.01
UCS_ReactomeCoreGenes Exclusive	Overlap	0.00	13.13	31.48	6.09	14.81
UCS_BaileyGenes Exclusive	Overlap	0.01	10.11	10.77	48.32	26.48
Overlap	Exclusives	0.01	2.18	15.97	4.64	8.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UCS_ReactomeCoreGenes Exclusive	3	3	
UCS_BaileyGenes Exclusive	12	12	
Overlap	2	2