Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
5Method_NoYahaya	Yahaya	1.31e-02	9.69e-02	2.11e-07	1.76e-10
Yahaya	5Method_NoYahaya	7.32e-07	9.49e-11	1.73e-46	4.09e-43



Evaluating how well 5Method_NoYahaya genes are linked to Yahaya genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
5Method_NoYahaya	Yahaya	0.76	1.77	2.32	1.79	8.16
Yahaya	5Method_NoYahaya	0.69	2.74	9.30	3.94	14.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
5Method_NoYahaya	Yahaya	0.03	2.69	14.49	4.56	38.47
Yahaya	5Method_NoYahaya	0.06	1.48	9.24	5.36	19.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
5Method_NoYahaya	558	558	
Yahaya	72	72