Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
youngpancanAC1 Exclusive	cosmic_germline	8.67e-23	1.17e-14	2.89e-29	3.06e-36
cosmic_germline Exclusive	youngpancanAC1	1.65e-18	1.38e-13	4.76e-34	2.63e-22
youngpancanAC1 Exclusive	cosmic_germline Exclusive	4.55e-14	3.08e-09	1.53e-19	2.23e-30
cosmic_germline Exclusive	youngpancanAC1 Exclusive	7.77e-14	3.38e-11	2.44e-24	2.03e-15
youngpancanAC1 Exclusive	Overlap	8.86e-22	2.55e-12	2.15e-28	7.84e-18
cosmic_germline Exclusive	Overlap	3.83e-31	8.97e-15	3.83e-31	4.59e-23
Overlap	Exclusives	1.40e-42	6.56e-41	1.30e-72	3.76e-74



Evaluating how well youngpancanAC1 genes are linked to cosmic_germline genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
youngpancanAC1 Exclusive	cosmic_germline	0.88	4.21	10.95	4.45	15.33
cosmic_germline Exclusive	youngpancanAC1	0.84	4.75	9.22	4.01	11.80
youngpancanAC1 Exclusive	cosmic_germline Exclusive	0.87	4.36	9.21	4.26	13.75
cosmic_germline Exclusive	youngpancanAC1 Exclusive	0.81	4.66	7.93	4.31	9.72
youngpancanAC1 Exclusive	Overlap	0.99	2.50	5.91	2.99	6.46
cosmic_germline Exclusive	Overlap	1.00	3.18	4.55	2.67	6.20
Overlap	Exclusives	0.89	5.55	15.40	5.02	17.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
youngpancanAC1 Exclusive	cosmic_germline	0.12	20.04	99.73	51.76	230.57
cosmic_germline Exclusive	youngpancanAC1	0.18	84.12	205.21	85.84	330.94
youngpancanAC1 Exclusive	cosmic_germline Exclusive	0.07	9.15	50.48	29.49	121.07
cosmic_germline Exclusive	youngpancanAC1 Exclusive	0.06	52.43	84.81	59.87	152.77
youngpancanAC1 Exclusive	Overlap	0.13	32.20	271.46	177.00	272.99
cosmic_germline Exclusive	Overlap	0.27	56.09	350.88	265.35	643.35
Overlap	Exclusives	0.18	41.36	142.72	59.12	248.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
youngpancanAC1 Exclusive	74	74	
cosmic_germline Exclusive	97	97	
Overlap	13	13