Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
youngpancanAC1 Exclusive	geneAge_directEvidence	1.03e-05	1.49e-03	1.98e-08	5.12e-10
geneAge_directEvidence Exclusive	youngpancanAC1	2.26e-13	1.32e-10	1.86e-33	1.92e-23
youngpancanAC1 Exclusive	geneAge_directEvidence Exclusive	2.09e-04	1.15e-02	5.32e-07	1.71e-08
geneAge_directEvidence Exclusive	youngpancanAC1 Exclusive	4.52e-12	3.68e-10	2.80e-31	1.84e-22
youngpancanAC1 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
geneAge_directEvidence Exclusive	Overlap	4.36e-07	2.28e-02	4.36e-07	1.74e-06
Overlap	Exclusives	3.04e-13	9.92e-17	1.12e-40	8.63e-32



Evaluating how well youngpancanAC1 genes are linked to geneAge_directEvidence genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
youngpancanAC1 Exclusive	geneAge_directEvidence	0.77	0.57	3.11	2.64	8.25
geneAge_directEvidence Exclusive	youngpancanAC1	0.84	3.84	9.35	4.36	12.18
youngpancanAC1 Exclusive	geneAge_directEvidence Exclusive	0.76	0.37	2.27	2.91	8.17
geneAge_directEvidence Exclusive	youngpancanAC1 Exclusive	0.83	4.50	9.10	3.96	12.17
youngpancanAC1 Exclusive	Overlap	1.00	2.04	2.24	1.93	3.09
geneAge_directEvidence Exclusive	Overlap	1.00	2.11	2.13	2.03	3.27
Overlap	Exclusives	0.83	2.84	10.03	2.63	14.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
youngpancanAC1 Exclusive	geneAge_directEvidence	0.03	2.42	24.95	18.10	13.66
geneAge_directEvidence Exclusive	youngpancanAC1	0.03	6.65	24.14	14.84	40.73
youngpancanAC1 Exclusive	geneAge_directEvidence Exclusive	0.01	0.57	9.89	11.49	19.87
geneAge_directEvidence Exclusive	youngpancanAC1 Exclusive	0.02	8.03	19.75	10.36	36.03
youngpancanAC1 Exclusive	Overlap	0.08	12.45	90.63	51.51	23.18
geneAge_directEvidence Exclusive	Overlap	0.02	3.30	6.26	19.35	32.54
Overlap	Exclusives	0.08	14.07	82.74	18.97	108.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
youngpancanAC1 Exclusive	84	84	
geneAge_directEvidence Exclusive	60	59	TERC
Overlap	3	3