Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
oldpancanAC1	cosmic_germline	8.04e-03	7.01e-01	7.15e-02	1.21e-07
cosmic_germline	oldpancanAC1	6.84e-03	7.69e-01	1.04e-02	4.74e-03



Evaluating how well oldpancanAC1 genes are linked to cosmic_germline genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
oldpancanAC1	cosmic_germline	0.66	-0.92	-1.24	-0.53	5.86
cosmic_germline	oldpancanAC1	0.57	0.46	-0.63	-0.02	2.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
oldpancanAC1	cosmic_germline	0.01	-1.29	-1.21	-0.76	2.35
cosmic_germline	oldpancanAC1	0.01	-1.27	-0.65	-0.46	0.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
oldpancanAC1	115	114	GBA3
cosmic_germline	110	110