Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
oldpancanAC1 Exclusive	baileyPancan	4.83e-16	2.95e-03	8.17e-05	1.22e-16
baileyPancan Exclusive	oldpancanAC1	5.87e-09	2.61e-03	6.07e-04	1.18e-01
oldpancanAC1 Exclusive	baileyPancan Exclusive	6.47e-16	6.42e-04	5.33e-06	2.03e-16
baileyPancan Exclusive	oldpancanAC1 Exclusive	3.53e-09	1.98e-03	8.72e-04	7.55e-02
oldpancanAC1 Exclusive	Overlap	3.50e-01	9.07e-02	9.71e-02	4.15e-02
baileyPancan Exclusive	Overlap	7.04e-01	7.89e-01	7.71e-02	8.78e-02
Overlap	Exclusives	1.24e-05	1.84e-09	1.29e-109	2.57e-49



Evaluating how well oldpancanAC1 genes are linked to baileyPancan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
oldpancanAC1 Exclusive	baileyPancan	0.66	-3.83	-3.49	-2.31	6.91
baileyPancan Exclusive	oldpancanAC1	0.52	-2.92	-4.25	-1.72	0.54
oldpancanAC1 Exclusive	baileyPancan Exclusive	0.65	-3.62	-4.05	-2.70	7.46
baileyPancan Exclusive	oldpancanAC1 Exclusive	0.51	-3.10	-3.58	-1.56	0.52
oldpancanAC1 Exclusive	Overlap	0.90	1.91	4.44	1.35	2.42
baileyPancan Exclusive	Overlap	0.69	-0.53	-0.69	-0.56	1.10
Overlap	Exclusives	0.76	5.59	7.42	1.96	17.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
oldpancanAC1 Exclusive	baileyPancan	0.01	-1.93	-3.31	-1.82	3.98
baileyPancan Exclusive	oldpancanAC1	0.01	-1.30	-1.58	-0.65	0.35
oldpancanAC1 Exclusive	baileyPancan Exclusive	0.01	-1.86	-3.55	-1.95	4.61
baileyPancan Exclusive	oldpancanAC1 Exclusive	0.01	-3.56	-2.74	-1.35	-0.67
oldpancanAC1 Exclusive	Overlap	0.00	-1.06	-8.33	-0.49	0.46
baileyPancan Exclusive	Overlap	0.04	-0.72	642.26	5.45	50.13
Overlap	Exclusives	0.04	9.86	11.38	2.39	24.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
oldpancanAC1 Exclusive	112	111	GBA3
baileyPancan Exclusive	197	197	
Overlap	3	3