Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
oldHealthyAC1 Exclusive	baileyPancan	1.25e-05	8.06e-02	6.89e-12	1.69e-29
baileyPancan Exclusive	oldHealthyAC1	1.52e-08	3.77e-04	1.97e-26	2.03e-05
oldHealthyAC1 Exclusive	baileyPancan Exclusive	1.25e-06	2.34e-01	3.01e-09	6.44e-27
baileyPancan Exclusive	oldHealthyAC1 Exclusive	7.92e-09	3.52e-04	5.40e-23	9.13e-04
oldHealthyAC1 Exclusive	Overlap	1.59e-03	4.75e-06	4.81e-07	3.65e-08
baileyPancan Exclusive	Overlap	7.60e-09	4.98e-06	1.78e-21	6.56e-12
Overlap	Exclusives	2.19e-20	1.56e-18	7.75e-60	1.58e-50



Evaluating how well oldHealthyAC1 genes are linked to baileyPancan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
oldHealthyAC1 Exclusive	baileyPancan	0.76	-2.37	1.37	-0.41	12.41
baileyPancan Exclusive	oldHealthyAC1	0.58	-0.90	-2.31	-0.36	5.08
oldHealthyAC1 Exclusive	baileyPancan Exclusive	0.75	-2.93	0.90	-0.57	12.76
baileyPancan Exclusive	oldHealthyAC1 Exclusive	0.56	-1.15	-2.24	-0.60	4.03
oldHealthyAC1 Exclusive	Overlap	0.94	1.46	3.20	1.66	4.66
baileyPancan Exclusive	Overlap	0.99	3.98	3.46	3.11	5.34
Overlap	Exclusives	0.74	2.65	8.33	2.69	18.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
oldHealthyAC1 Exclusive	baileyPancan	0.03	-2.48	3.54	-1.22	16.44
baileyPancan Exclusive	oldHealthyAC1	0.03	3.68	9.32	4.65	15.25
oldHealthyAC1 Exclusive	baileyPancan Exclusive	0.03	-2.60	2.77	-1.22	18.18
baileyPancan Exclusive	oldHealthyAC1 Exclusive	0.02	0.23	1.25	1.13	7.05
oldHealthyAC1 Exclusive	Overlap	0.00	-0.44	5.89	0.48	4.79
baileyPancan Exclusive	Overlap	0.13	27.89	79.99	144.79	71.78
Overlap	Exclusives	0.10	5.73	33.50	16.48	74.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
oldHealthyAC1 Exclusive	268	268	
baileyPancan Exclusive	191	191	
Overlap	9	9