Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
oldHealthyAC1 Exclusive	geneAge_directEvidence	7.65e-04	1.26e-03	6.57e-11	2.28e-12
geneAge_directEvidence Exclusive	oldHealthyAC1	5.18e-06	8.08e-04	5.93e-14	2.18e-06
oldHealthyAC1 Exclusive	geneAge_directEvidence Exclusive	1.14e-03	2.47e-03	2.68e-10	5.00e-12
geneAge_directEvidence Exclusive	oldHealthyAC1 Exclusive	9.78e-06	8.36e-04	2.80e-13	4.31e-06
oldHealthyAC1 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	7.92e-02
geneAge_directEvidence Exclusive	Overlap	3.96e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	7.54e-10	1.55e-01	3.84e-53	3.46e-17



Evaluating how well oldHealthyAC1 genes are linked to geneAge_directEvidence genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
oldHealthyAC1 Exclusive	geneAge_directEvidence	0.79	0.63	3.77	2.31	6.69
geneAge_directEvidence Exclusive	oldHealthyAC1	0.62	1.71	1.03	1.24	7.30
oldHealthyAC1 Exclusive	geneAge_directEvidence Exclusive	0.78	0.73	3.71	2.20	7.58
geneAge_directEvidence Exclusive	oldHealthyAC1 Exclusive	0.62	1.84	1.01	0.85	6.65
oldHealthyAC1 Exclusive	Overlap	0.96	0.76	1.35	1.25	1.87
geneAge_directEvidence Exclusive	Overlap	0.98	0.60	1.26	1.68	1.70
Overlap	Exclusives	0.65	2.41	0.96	0.69	9.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
oldHealthyAC1 Exclusive	geneAge_directEvidence	0.01	-1.12	5.57	1.08	4.10
geneAge_directEvidence Exclusive	oldHealthyAC1	0.03	4.26	3.67	6.37	12.54
oldHealthyAC1 Exclusive	geneAge_directEvidence Exclusive	0.01	-1.09	5.75	0.69	10.61
geneAge_directEvidence Exclusive	oldHealthyAC1 Exclusive	0.03	4.82	3.55	4.09	15.60
oldHealthyAC1 Exclusive	Overlap	0.00	0.02	2.90	1.62	1.76
geneAge_directEvidence Exclusive	Overlap	0.00	-0.23	14.17	2.64	9.05
Overlap	Exclusives	0.03	4.37	3.72	1.24	14.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
oldHealthyAC1 Exclusive	276	276	
geneAge_directEvidence Exclusive	62	61	TERC
Overlap	1	1