Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Mu_geneset02062023 Exclusive	Gwas_gs	1.98e-01	1.21e-01	2.44e-01	8.01e-04
Gwas_gs Exclusive	Mu_geneset02062023	3.41e-01	1.27e-01	1.33e-04	2.57e-01
Mu_geneset02062023 Exclusive	Gwas_gs Exclusive	2.07e-01	1.58e-01	2.69e-01	5.76e-04
Gwas_gs Exclusive	Mu_geneset02062023 Exclusive	5.67e-01	3.40e-01	7.29e-04	4.42e-01
Mu_geneset02062023 Exclusive	Overlap	7.49e-01	8.93e-01	8.33e-01	6.43e-01
Gwas_gs Exclusive	Overlap	1.17e-01	9.69e-02	1.05e-01	1.95e-01
Overlap	Exclusives	2.00e-02	1.31e-01	2.05e-01	2.78e-03



Evaluating how well Mu_geneset02062023 genes are linked to Gwas_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Mu_geneset02062023 Exclusive	Gwas_gs	0.62	1.33	1.92	1.44	3.94
Gwas_gs Exclusive	Mu_geneset02062023	0.53	1.95	1.79	1.82	1.53
Mu_geneset02062023 Exclusive	Gwas_gs Exclusive	0.64	1.81	2.35	1.83	3.84
Gwas_gs Exclusive	Mu_geneset02062023 Exclusive	0.53	1.61	1.55	1.62	1.47
Mu_geneset02062023 Exclusive	Overlap	0.45	-0.47	-0.21	-0.28	-0.45
Gwas_gs Exclusive	Overlap	0.63	2.15	2.23	1.42	1.26
Overlap	Exclusives	0.56	1.35	2.21	1.92	3.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Mu_geneset02062023 Exclusive	Gwas_gs	0.01	1.11	1.01	1.26	2.85
Gwas_gs Exclusive	Mu_geneset02062023	0.01	1.26	3.42	2.92	1.89
Mu_geneset02062023 Exclusive	Gwas_gs Exclusive	0.01	1.43	1.63	1.86	4.24
Gwas_gs Exclusive	Mu_geneset02062023 Exclusive	0.01	0.99	2.19	0.82	0.80
Mu_geneset02062023 Exclusive	Overlap	0.00	-0.66	-0.40	-0.54	-0.12
Gwas_gs Exclusive	Overlap	0.01	54.96	25.32	36.77	11.24
Overlap	Exclusives	0.02	2.25	3.18	2.51	2.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Mu_geneset02062023 Exclusive	153	153	
Gwas_gs Exclusive	71	70	CASC16
Overlap	6	6