Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mudiff_	singleton	3.73e-03	8.14e-05	1.02e-03	9.00e-09
singleton	mudiff_	8.81e-02	3.84e-01	3.22e-12	3.14e-01



Evaluating how well mudiff_ genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mudiff_	singleton	0.86	2.80	4.47	3.42	5.92
singleton	mudiff_	0.53	2.62	1.36	2.03	1.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mudiff_	singleton	0.01	3.69	11.06	5.55	11.72
singleton	mudiff_	0.01	9.36	1.95	4.10	3.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mudiff_	159	159	
singleton	21	20	LRP10