Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mudiff_	gos_sing	1.22e-02	2.07e-02	1.06e-02	3.13e-04
gos_sing	mudiff_	8.14e-02	6.66e-01	3.35e-20	4.98e-01



Evaluating how well mudiff_ genes are linked to gos_sing genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mudiff_	gos_sing	0.82	0.96	1.70	1.40	3.79
gos_sing	mudiff_	0.51	0.62	0.60	0.98	0.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mudiff_	gos_sing	0.00	2.12	5.19	4.21	10.71
gos_sing	mudiff_	0.01	1.82	2.15	1.68	0.90

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mudiff_	159	159	
gos_sing	12	12