Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mudiff_ Exclusive	sis_sing	7.91e-01	6.05e-01	8.18e-01	5.45e-01
sis_sing Exclusive	mudiff_	3.19e-01	4.54e-01	3.72e-02	5.44e-01
mudiff_ Exclusive	sis_sing Exclusive	4.77e-01	4.38e-01	7.03e-01	5.91e-01
sis_sing Exclusive	mudiff_ Exclusive	4.09e-01	5.06e-01	1.68e-01	6.66e-01
mudiff_ Exclusive	Overlap	6.53e-01	4.55e-01	5.94e-01	7.13e-01
sis_sing Exclusive	Overlap	1.98e-02	7.92e-02	1.98e-02	1.98e-02
Overlap	Exclusives	7.00e-04	2.58e-01	8.79e-08	2.45e-01



Evaluating how well mudiff_ genes are linked to sis_sing genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mudiff_ Exclusive	sis_sing	0.59	0.52	0.63	0.55	1.17
sis_sing Exclusive	mudiff_	0.50	0.66	0.41	0.38	0.05
mudiff_ Exclusive	sis_sing Exclusive	0.58	0.59	0.62	0.41	0.80
sis_sing Exclusive	mudiff_ Exclusive	0.50	0.58	0.27	0.10	-0.41
mudiff_ Exclusive	Overlap	0.71	0.70	0.76	0.57	0.61
sis_sing Exclusive	Overlap	0.99	2.27	1.67	2.24	1.76
Overlap	Exclusives	0.52	0.63	1.02	0.46	0.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mudiff_ Exclusive	sis_sing	0.00	0.91	2.47	0.76	0.87
sis_sing Exclusive	mudiff_	0.01	0.78	0.39	0.50	0.87
mudiff_ Exclusive	sis_sing Exclusive	0.00	1.90	2.44	0.86	0.91
sis_sing Exclusive	mudiff_ Exclusive	0.01	0.45	0.24	0.39	0.15
mudiff_ Exclusive	Overlap	0.00	0.03	-0.14	-0.17	-0.23
sis_sing Exclusive	Overlap	0.00	29.88	3.58	21.99	23.13
Overlap	Exclusives	0.01	0.67	2.31	1.04	1.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mudiff_ Exclusive	158	158	
sis_sing Exclusive	10	10	
Overlap	1	1