Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
lbd_mudiff Exclusive	singleton_lbd	5.20e-01	1.99e-01	5.79e-01	3.43e-04
singleton_lbd Exclusive	lbd_mudiff	1.45e-01	5.88e-01	1.43e-09	8.04e-01
lbd_mudiff Exclusive	singleton_lbd Exclusive	3.37e-01	9.82e-02	3.49e-01	1.04e-04
singleton_lbd Exclusive	lbd_mudiff Exclusive	1.35e-01	7.17e-01	1.73e-09	7.83e-01
lbd_mudiff Exclusive	Overlap	2.57e-01	4.55e-01	4.55e-01	9.11e-01
singleton_lbd Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.47e-07	1.69e-03	8.38e-36	9.81e-05



Evaluating how well lbd_mudiff genes are linked to singleton_lbd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
lbd_mudiff Exclusive	singleton_lbd	0.74	0.58	1.49	0.50	3.97
singleton_lbd Exclusive	lbd_mudiff	0.50	0.31	-0.63	-0.41	-0.20
lbd_mudiff Exclusive	singleton_lbd Exclusive	0.74	0.88	1.52	0.99	3.60
singleton_lbd Exclusive	lbd_mudiff Exclusive	0.49	0.04	-0.58	-0.49	-0.35
lbd_mudiff Exclusive	Overlap	0.61	-1.25	-1.06	-0.72	0.19
singleton_lbd Exclusive	Overlap	1.00	2.76	1.94	2.05	1.78
Overlap	Exclusives	0.57	3.89	3.42	2.43	3.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
lbd_mudiff Exclusive	singleton_lbd	0.00	1.08	1.49	1.09	6.33
singleton_lbd Exclusive	lbd_mudiff	0.01	1.89	3.43	2.33	1.90
lbd_mudiff Exclusive	singleton_lbd Exclusive	0.00	1.45	1.00	2.04	1.57
singleton_lbd Exclusive	lbd_mudiff Exclusive	0.01	0.97	1.13	0.55	0.62
lbd_mudiff Exclusive	Overlap	0.00	-0.49	-0.75	-0.56	-0.34
singleton_lbd Exclusive	Overlap	0.08	611.57	295.51	98.43	88.19
Overlap	Exclusives	0.02	6.24	2.88	3.16	4.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
lbd_mudiff Exclusive	200	200	
singleton_lbd Exclusive	20	19	VPS35 
Overlap	1	1