Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
lbd_mudiff	AD-Ismael	5.24e-02	9.26e-02	7.85e-02	1.76e-04
AD-Ismael	lbd_mudiff	1.87e-02	3.59e-01	2.98e-09	3.24e-01



Evaluating how well lbd_mudiff genes are linked to AD-Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
lbd_mudiff	AD-Ismael	0.80	2.21	2.66	1.93	3.81
AD-Ismael	lbd_mudiff	0.52	1.65	1.65	1.14	1.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
lbd_mudiff	AD-Ismael	0.00	1.29	1.53	1.68	6.76
AD-Ismael	lbd_mudiff	0.01	0.75	1.75	1.23	1.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
lbd_mudiff	201	201	
AD-Ismael	14	14