Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
lbd_mudiff Exclusive	lbd_gs	8.78e-01	4.31e-01	9.28e-01	8.16e-02
lbd_gs Exclusive	lbd_mudiff	1.04e-01	3.10e-01	2.45e-47	6.12e-01
lbd_mudiff Exclusive	lbd_gs Exclusive	8.00e-01	9.12e-01	8.69e-01	6.85e-02
lbd_gs Exclusive	lbd_mudiff Exclusive	1.15e-01	3.60e-01	9.09e-44	5.19e-01
lbd_mudiff Exclusive	Overlap	6.93e-01	5.17e-01	7.79e-01	4.12e-01
lbd_gs Exclusive	Overlap	9.85e-05	9.85e-05	5.91e-04	9.85e-04
Overlap	Exclusives	1.59e-03	2.93e-02	1.92e-50	1.21e-02



Evaluating how well lbd_mudiff genes are linked to lbd_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
lbd_mudiff Exclusive	lbd_gs	0.81	0.33	0.98	0.42	2.45
lbd_gs Exclusive	lbd_mudiff	0.53	2.40	1.62	1.25	1.11
lbd_mudiff Exclusive	lbd_gs Exclusive	0.83	0.93	1.39	1.11	2.34
lbd_gs Exclusive	lbd_mudiff Exclusive	0.52	2.46	1.65	1.31	1.53
lbd_mudiff Exclusive	Overlap	0.78	-1.05	-1.23	-0.97	1.30
lbd_gs Exclusive	Overlap	0.99	3.74	2.73	2.26	2.46
Overlap	Exclusives	0.54	2.54	2.59	2.26	2.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
lbd_mudiff Exclusive	lbd_gs	0.00	0.67	1.19	1.17	1.78
lbd_gs Exclusive	lbd_mudiff	0.01	3.18	1.53	1.98	1.50
lbd_mudiff Exclusive	lbd_gs Exclusive	0.00	0.78	0.22	1.70	14.33
lbd_gs Exclusive	lbd_mudiff Exclusive	0.01	2.17	1.47	1.31	1.72
lbd_mudiff Exclusive	Overlap	0.00	-0.26	0.55	-0.34	0.04
lbd_gs Exclusive	Overlap	0.01	53.30	68.08	30.20	30.43
Overlap	Exclusives	0.01	2.64	1.33	1.41	1.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
lbd_mudiff Exclusive	199	199	
lbd_gs Exclusive	4	4	
Overlap	2	2