Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Common_2methodConsensus	BRCA-somatic	2.39e-04	1.63e-02	1.73e-05	1.64e-12
BRCA-somatic	Common_2methodConsensus	3.45e-01	5.02e-01	1.95e-03	2.40e-01



Evaluating how well Common_2methodConsensus genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common_2methodConsensus	BRCA-somatic	0.84	1.93	2.69	1.77	7.36
BRCA-somatic	Common_2methodConsensus	0.59	0.27	0.87	0.72	1.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common_2methodConsensus	BRCA-somatic	0.01	2.03	3.25	1.88	10.94
BRCA-somatic	Common_2methodConsensus	0.00	0.03	2.22	1.32	1.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Common_2methodConsensus	28	28	
BRCA-somatic	37	37