Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Common_funcConsensus Exclusive	BRCA-familial	2.71e-20	2.96e-12	5.35e-36	2.42e-24
BRCA-familial Exclusive	Common_funcConsensus	2.06e-06	7.30e-06	2.65e-16	1.79e-17
Common_funcConsensus Exclusive	BRCA-familial Exclusive	1.61e-19	3.39e-11	2.98e-33	2.05e-22
BRCA-familial Exclusive	Common_funcConsensus Exclusive	6.95e-06	5.04e-06	3.97e-15	2.12e-16
Common_funcConsensus Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
BRCA-familial Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.23e-17	6.22e-14	5.55e-45	5.36e-29



Evaluating how well Common_funcConsensus genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common_funcConsensus Exclusive	BRCA-familial	0.99	2.68	6.01	2.91	7.88
BRCA-familial Exclusive	Common_funcConsensus	0.82	1.89	5.74	3.34	10.16
Common_funcConsensus Exclusive	BRCA-familial Exclusive	0.99	2.76	6.14	3.16	8.79
BRCA-familial Exclusive	Common_funcConsensus Exclusive	0.82	2.06	5.43	3.60	10.46
Common_funcConsensus Exclusive	Overlap	1.00	0.80	1.71	1.36	1.69
BRCA-familial Exclusive	Overlap	1.00	1.22	6.79	1.74	1.81
Overlap	Exclusives	0.86	3.90	7.13	2.47	11.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common_funcConsensus Exclusive	BRCA-familial	0.24	17.10	163.44	177.32	439.15
BRCA-familial Exclusive	Common_funcConsensus	0.05	10.52	53.59	38.88	82.56
Common_funcConsensus Exclusive	BRCA-familial Exclusive	0.21	15.91	128.36	143.43	599.17
BRCA-familial Exclusive	Common_funcConsensus Exclusive	0.05	10.24	50.12	38.58	84.29
Common_funcConsensus Exclusive	Overlap	0.06	2.05	547.23	134.70	210.27
BRCA-familial Exclusive	Overlap	0.01	2.53	107.48	15.08	74.31
Overlap	Exclusives	0.04	36.23	36.07	8.85	30.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Common_funcConsensus Exclusive	71	71	
BRCA-familial Exclusive	22	22	
Overlap	1	1