Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Common_funcConsensus Exclusive	BRCA-somatic	1.37e-04	1.44e-02	5.72e-10	4.11e-12
BRCA-somatic Exclusive	Common_funcConsensus	7.73e-03	1.03e-05	1.54e-23	6.93e-16
Common_funcConsensus Exclusive	BRCA-somatic Exclusive	1.20e-02	1.82e-01	5.47e-07	6.02e-10
BRCA-somatic Exclusive	Common_funcConsensus Exclusive	2.69e-02	4.39e-05	1.78e-21	1.54e-13
Common_funcConsensus Exclusive	Overlap	1.88e-09	3.07e-03	7.45e-12	1.52e-07
BRCA-somatic Exclusive	Overlap	4.17e-10	7.20e-04	7.45e-12	8.67e-08
Overlap	Exclusives	3.56e-19	1.35e-14	7.72e-42	1.45e-35



Evaluating how well Common_funcConsensus genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common_funcConsensus Exclusive	BRCA-somatic	0.87	-0.69	1.85	2.23	7.60
BRCA-somatic Exclusive	Common_funcConsensus	0.77	-0.80	3.96	2.46	9.22
Common_funcConsensus Exclusive	BRCA-somatic Exclusive	0.85	-0.46	1.34	1.89	7.10
BRCA-somatic Exclusive	Common_funcConsensus Exclusive	0.76	-0.84	3.66	2.35	7.39
Common_funcConsensus Exclusive	Overlap	0.99	1.21	2.29	2.42	4.30
BRCA-somatic Exclusive	Overlap	0.99	1.23	2.26	2.44	3.48
Overlap	Exclusives	0.87	4.16	8.23	3.01	10.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common_funcConsensus Exclusive	BRCA-somatic	0.02	-1.01	7.71	7.33	24.67
BRCA-somatic Exclusive	Common_funcConsensus	0.01	-0.46	4.30	6.82	6.62
Common_funcConsensus Exclusive	BRCA-somatic Exclusive	0.01	-1.36	3.49	3.38	21.78
BRCA-somatic Exclusive	Common_funcConsensus Exclusive	0.01	-0.63	1.67	5.21	10.76
Common_funcConsensus Exclusive	Overlap	0.02	2.12	22.18	21.54	36.64
BRCA-somatic Exclusive	Overlap	0.02	1.62	24.97	31.84	40.01
Overlap	Exclusives	0.04	7.98	27.11	14.22	30.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Common_funcConsensus Exclusive	67	67	
BRCA-somatic Exclusive	32	32	
Overlap	5	5