Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Common_ComboConsensus Exclusive	BRCA-somatic	3.52e-04	3.29e-02	4.80e-11	1.19e-15
BRCA-somatic Exclusive	Common_ComboConsensus	3.72e-02	1.66e-04	4.96e-22	2.40e-12
Common_ComboConsensus Exclusive	BRCA-somatic Exclusive	2.37e-02	3.34e-01	7.18e-08	1.82e-12
BRCA-somatic Exclusive	Common_ComboConsensus Exclusive	5.12e-02	2.69e-04	9.39e-19	9.10e-11
Common_ComboConsensus Exclusive	Overlap	2.51e-07	2.50e-03	7.45e-12	6.39e-08
BRCA-somatic Exclusive	Overlap	2.24e-08	6.21e-04	7.45e-12	3.26e-08
Overlap	Exclusives	2.03e-17	1.33e-12	1.75e-34	4.01e-28



Evaluating how well Common_ComboConsensus genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common_ComboConsensus Exclusive	BRCA-somatic	0.89	0.16	1.61	2.00	8.48
BRCA-somatic Exclusive	Common_ComboConsensus	0.72	-1.22	3.46	2.78	7.96
Common_ComboConsensus Exclusive	BRCA-somatic Exclusive	0.87	0.08	1.20	1.74	6.64
BRCA-somatic Exclusive	Common_ComboConsensus Exclusive	0.71	-1.17	3.19	2.47	6.96
Common_ComboConsensus Exclusive	Overlap	0.99	1.31	2.22	2.07	3.76
BRCA-somatic Exclusive	Overlap	0.99	1.18	2.73	2.67	4.02
Overlap	Exclusives	0.80	4.08	6.51	2.89	12.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common_ComboConsensus Exclusive	BRCA-somatic	0.02	-0.63	7.86	7.25	44.53
BRCA-somatic Exclusive	Common_ComboConsensus	0.02	-0.55	4.90	7.82	12.28
Common_ComboConsensus Exclusive	BRCA-somatic Exclusive	0.01	-1.03	2.52	3.12	13.59
BRCA-somatic Exclusive	Common_ComboConsensus Exclusive	0.01	-0.64	2.58	5.19	10.56
Common_ComboConsensus Exclusive	Overlap	0.02	0.44	18.28	21.83	47.76
BRCA-somatic Exclusive	Overlap	0.02	0.16	29.18	42.95	52.65
Overlap	Exclusives	0.04	8.38	22.17	13.36	29.60

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Common_ComboConsensus Exclusive	91	91	
BRCA-somatic Exclusive	32	32	
Overlap	5	5