Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Common_ComboConsensus Exclusive	BRCA-gwas	9.20e-03	2.12e-01	7.68e-10	6.31e-06
BRCA-gwas Exclusive	Common_ComboConsensus	1.54e-01	2.73e-02	5.66e-13	1.15e-12
Common_ComboConsensus Exclusive	BRCA-gwas Exclusive	2.17e-02	3.03e-01	5.21e-09	7.44e-06
BRCA-gwas Exclusive	Common_ComboConsensus Exclusive	1.77e-01	1.58e-02	5.95e-13	2.20e-12
Common_ComboConsensus Exclusive	Overlap	2.04e-01	3.04e-01	7.71e-02	1.45e-01
BRCA-gwas Exclusive	Overlap	8.36e-01	8.36e-01	6.58e-01	2.82e-01
Overlap	Exclusives	2.84e-01	4.32e-01	2.50e-19	6.15e-15



Evaluating how well Common_ComboConsensus genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common_ComboConsensus Exclusive	BRCA-gwas	0.63	0.34	0.40	1.42	5.90
BRCA-gwas Exclusive	Common_ComboConsensus	0.74	0.89	3.37	2.99	8.44
Common_ComboConsensus Exclusive	BRCA-gwas Exclusive	0.63	0.25	0.59	1.79	5.53
BRCA-gwas Exclusive	Common_ComboConsensus Exclusive	0.74	0.70	3.59	2.50	7.70
Common_ComboConsensus Exclusive	Overlap	0.72	-0.58	-0.07	0.62	1.33
BRCA-gwas Exclusive	Overlap	0.74	0.08	0.23	0.74	1.32
Overlap	Exclusives	0.66	0.30	2.08	1.03	10.58

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common_ComboConsensus Exclusive	BRCA-gwas	0.02	0.96	6.17	6.71	12.37
BRCA-gwas Exclusive	Common_ComboConsensus	0.02	2.32	6.00	10.14	23.81
Common_ComboConsensus Exclusive	BRCA-gwas Exclusive	0.02	0.83	6.21	6.90	10.62
BRCA-gwas Exclusive	Common_ComboConsensus Exclusive	0.02	2.16	6.07	8.46	12.42
Common_ComboConsensus Exclusive	Overlap	0.00	0.32	3.33	10.07	2.32
BRCA-gwas Exclusive	Overlap	0.00	-0.24	0.49	0.30	1.05
Overlap	Exclusives	0.02	1.12	3.38	1.39	11.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Common_ComboConsensus Exclusive	93	93	
BRCA-gwas Exclusive	170	170	
Overlap	3	3