Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) Rare_funcConsensus Exclusive BRCA-somatic 5.12e-05 6.78e-05 6.52e-27 2.15e-24 BRCA-somatic Exclusive Rare_funcConsensus 2.21e-11 4.31e-05 9.92e-48 8.46e-31 Rare_funcConsensus Exclusive BRCA-somatic Exclusive 8.40e-04 7.79e-03 5.10e-20 2.30e-17 BRCA-somatic Exclusive Rare_funcConsensus Exclusive 4.71e-09 4.85e-04 2.94e-42 2.53e-27 Rare_funcConsensus Exclusive Overlap 4.20e-05 4.20e-05 4.60e-19 4.39e-11 BRCA-somatic Exclusive Overlap 4.60e-19 1.39e-11 4.60e-19 2.96e-15 Overlap Exclusives 1.43e-22 1.85e-11 4.21e-67 8.70e-55 Evaluating how well Rare_funcConsensus genes are linked to BRCA-somatic genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Rare_funcConsensus Exclusive BRCA-somatic 0.95 1.34 5.18 3.52 8.85 BRCA-somatic Exclusive Rare_funcConsensus 0.78 -1.45 4.85 3.64 13.16 Rare_funcConsensus Exclusive BRCA-somatic Exclusive 0.94 1.08 3.81 3.52 7.35 BRCA-somatic Exclusive Rare_funcConsensus Exclusive 0.77 -1.71 4.45 3.47 12.67 Rare_funcConsensus Exclusive Overlap 0.99 1.25 3.84 2.64 4.25 BRCA-somatic Exclusive Overlap 0.99 1.67 4.09 3.58 4.85 Overlap Exclusives 0.83 6.19 8.62 3.62 16.63 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Rare_funcConsensus Exclusive BRCA-somatic 0.06 -1.45 19.13 10.98 91.89 BRCA-somatic Exclusive Rare_funcConsensus 0.05 1.17 13.25 18.08 47.93 Rare_funcConsensus Exclusive BRCA-somatic Exclusive 0.03 -2.36 7.27 7.22 6.07 BRCA-somatic Exclusive Rare_funcConsensus Exclusive 0.04 0.90 10.47 13.70 31.44 Rare_funcConsensus Exclusive Overlap 0.04 1.45 37.83 17.02 81.50 BRCA-somatic Exclusive Overlap 0.04 2.05 62.12 89.52 85.67 Overlap Exclusives 0.07 11.49 17.84 17.37 75.17 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes Rare_funcConsensus Exclusive 179 178 BRCA-somatic Exclusive 29 29 Overlap 8 8