Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Rare_ComboConsensus Exclusive	BRCA-somatic	8.29e-05	2.00e-05	2.44e-23	4.36e-28
BRCA-somatic Exclusive	Rare_ComboConsensus	5.64e-10	3.05e-03	5.22e-41	2.34e-24
Rare_ComboConsensus Exclusive	BRCA-somatic Exclusive	7.66e-04	1.70e-03	7.71e-19	1.57e-21
BRCA-somatic Exclusive	Rare_ComboConsensus Exclusive	4.58e-09	9.58e-03	1.57e-35	3.44e-22
Rare_ComboConsensus Exclusive	Overlap	5.00e-05	4.87e-04	4.60e-19	2.69e-12
BRCA-somatic Exclusive	Overlap	4.60e-19	2.69e-12	4.60e-19	1.12e-14
Overlap	Exclusives	7.55e-18	2.93e-09	8.63e-55	7.71e-39



Evaluating how well Rare_ComboConsensus genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare_ComboConsensus Exclusive	BRCA-somatic	0.95	1.68	5.23	3.62	10.38
BRCA-somatic Exclusive	Rare_ComboConsensus	0.71	-0.59	3.68	3.28	11.58
Rare_ComboConsensus Exclusive	BRCA-somatic Exclusive	0.94	1.70	3.69	3.56	8.77
BRCA-somatic Exclusive	Rare_ComboConsensus Exclusive	0.70	-0.56	3.33	3.40	10.26
Rare_ComboConsensus Exclusive	Overlap	0.99	1.30	3.18	2.28	4.85
BRCA-somatic Exclusive	Overlap	0.99	1.83	3.66	2.96	5.57
Overlap	Exclusives	0.75	5.66	8.51	3.66	14.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare_ComboConsensus Exclusive	BRCA-somatic	0.06	-1.13	20.91	5.23	22.13
BRCA-somatic Exclusive	Rare_ComboConsensus	0.05	1.63	10.00	12.46	32.17
Rare_ComboConsensus Exclusive	BRCA-somatic Exclusive	0.04	-1.62	12.32	3.34	83.91
BRCA-somatic Exclusive	Rare_ComboConsensus Exclusive	0.04	1.39	7.43	12.18	25.00
Rare_ComboConsensus Exclusive	Overlap	0.04	1.50	30.53	10.67	106.27
BRCA-somatic Exclusive	Overlap	0.04	2.97	57.80	52.80	2.69
Overlap	Exclusives	0.06	12.11	20.09	14.80	44.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Rare_ComboConsensus Exclusive	249	247	;PRAMEF11
BRCA-somatic Exclusive	29	29	
Overlap	8	8