Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Rare_ComboConsensus Exclusive	BRCA-gwas	5.23e-02	2.57e-01	1.27e-17	1.78e-08
BRCA-gwas Exclusive	Rare_ComboConsensus	2.46e-02	5.80e-02	4.36e-21	9.73e-28
Rare_ComboConsensus Exclusive	BRCA-gwas Exclusive	8.33e-02	4.31e-01	1.38e-15	5.26e-07
BRCA-gwas Exclusive	Rare_ComboConsensus Exclusive	6.80e-02	1.04e-01	1.24e-18	1.47e-24
Rare_ComboConsensus Exclusive	Overlap	4.57e-03	3.03e-02	4.46e-08	1.67e-08
BRCA-gwas Exclusive	Overlap	1.59e-03	2.14e-03	8.28e-07	1.37e-07
Overlap	Exclusives	3.38e-08	3.36e-07	4.07e-48	3.58e-33



Evaluating how well Rare_ComboConsensus genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare_ComboConsensus Exclusive	BRCA-gwas	0.65	0.01	1.76	2.43	6.97
BRCA-gwas Exclusive	Rare_ComboConsensus	0.72	0.69	2.85	2.89	11.51
Rare_ComboConsensus Exclusive	BRCA-gwas Exclusive	0.63	-0.10	1.19	2.32	5.55
BRCA-gwas Exclusive	Rare_ComboConsensus Exclusive	0.71	0.35	2.37	2.78	10.72
Rare_ComboConsensus Exclusive	Overlap	0.96	1.61	2.78	2.81	5.15
BRCA-gwas Exclusive	Overlap	0.95	1.80	3.13	3.05	6.29
Overlap	Exclusives	0.70	3.75	6.16	3.46	13.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare_ComboConsensus Exclusive	BRCA-gwas	0.02	-0.79	5.85	5.82	21.40
BRCA-gwas Exclusive	Rare_ComboConsensus	0.05	2.20	6.50	8.49	36.72
Rare_ComboConsensus Exclusive	BRCA-gwas Exclusive	0.02	-0.96	3.13	5.14	8.36
BRCA-gwas Exclusive	Rare_ComboConsensus Exclusive	0.04	0.78	3.91	5.94	26.01
Rare_ComboConsensus Exclusive	Overlap	0.02	-0.00	10.45	7.59	7.94
BRCA-gwas Exclusive	Overlap	0.05	8.96	8.43	35.44	72.92
Overlap	Exclusives	0.05	3.48	9.91	9.75	30.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Rare_ComboConsensus Exclusive	246	244	;PRAMEF11
BRCA-gwas Exclusive	162	162	
Overlap	11	11