Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
RareAndCommon_ComboConsensus Exclusive	BRCA-somatic	2.71e-03	2.48e-02	2.36e-19	5.52e-25
BRCA-somatic Exclusive	RareAndCommon_ComboConsensus	5.25e-07	4.84e-03	1.93e-44	2.25e-26
RareAndCommon_ComboConsensus Exclusive	BRCA-somatic Exclusive	3.27e-01	3.85e-02	1.32e-13	5.58e-18
BRCA-somatic Exclusive	RareAndCommon_ComboConsensus Exclusive	2.32e-05	5.61e-03	4.32e-44	8.26e-24
RareAndCommon_ComboConsensus Exclusive	Overlap	2.47e-06	6.86e-06	2.64e-26	2.02e-16
BRCA-somatic Exclusive	Overlap	4.06e-11	1.75e-09	3.16e-25	1.59e-15
Overlap	Exclusives	2.07e-20	1.25e-12	2.50e-65	2.86e-42



Evaluating how well RareAndCommon_ComboConsensus genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
RareAndCommon_ComboConsensus Exclusive	BRCA-somatic	0.94	0.85	4.03	2.70	9.83
BRCA-somatic Exclusive	RareAndCommon_ComboConsensus	0.69	-1.69	3.51	2.46	13.71
RareAndCommon_ComboConsensus Exclusive	BRCA-somatic Exclusive	0.92	0.66	3.52	2.61	8.10
BRCA-somatic Exclusive	RareAndCommon_ComboConsensus Exclusive	0.68	-1.89	3.45	2.99	10.00
RareAndCommon_ComboConsensus Exclusive	Overlap	0.99	1.93	3.76	2.48	5.98
BRCA-somatic Exclusive	Overlap	0.99	1.97	3.60	3.46	5.46
Overlap	Exclusives	0.73	3.77	6.75	3.73	15.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
RareAndCommon_ComboConsensus Exclusive	BRCA-somatic	0.12	1.84	31.43	8.73	240.09
BRCA-somatic Exclusive	RareAndCommon_ComboConsensus	0.05	0.32	8.08	8.24	28.98
RareAndCommon_ComboConsensus Exclusive	BRCA-somatic Exclusive	0.10	1.28	53.16	5.61	357.81
BRCA-somatic Exclusive	RareAndCommon_ComboConsensus Exclusive	0.04	0.09	5.36	8.38	18.74
RareAndCommon_ComboConsensus Exclusive	Overlap	0.06	3.10	28.73	11.31	153.15
BRCA-somatic Exclusive	Overlap	0.03	1.18	32.21	52.16	16.82
Overlap	Exclusives	0.08	7.90	16.56	15.96	54.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
RareAndCommon_ComboConsensus Exclusive	380	378	;PRAMEF11
BRCA-somatic Exclusive	26	26	
Overlap	11	11