Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
136_mutrain	singleton	8.76e-01	8.40e-01	4.82e-01	1.26e-02
singleton	136_mutrain	5.12e-02	8.58e-01	1.14e-07	9.02e-01



Evaluating how well 136_mutrain genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
136_mutrain	singleton	0.71	-0.30	0.11	0.25	3.59
singleton	136_mutrain	0.51	-0.44	-0.47	0.33	0.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
136_mutrain	singleton	0.00	-0.26	0.36	0.45	4.50
singleton	136_mutrain	0.01	0.23	-0.24	0.50	0.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
136_mutrain	136	135	AP000781.2
singleton	21	21