Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
eaml	singleton	8.31e-01	6.62e-01	9.21e-01	1.17e-02
singleton	eaml	1.69e-04	5.89e-02	8.54e-09	5.42e-02



Evaluating how well eaml genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml	singleton	0.66	-0.39	-0.64	-0.23	2.74
singleton	eaml	0.48	-0.91	-0.98	-0.54	-0.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml	singleton	0.00	-0.40	-0.49	-0.36	0.65
singleton	eaml	0.01	-0.17	-0.48	-0.02	-0.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
eaml	103	103	
singleton	21	21