Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) eaml Exclusive gwas 9.42e-01 8.80e-01 9.27e-01 5.03e-02 gwas Exclusive eaml 5.65e-01 4.44e-01 6.37e-03 5.45e-01 eaml Exclusive gwas Exclusive 7.93e-01 7.67e-01 7.95e-01 3.44e-02 gwas Exclusive eaml Exclusive 4.52e-01 3.83e-01 7.10e-03 5.41e-01 eaml Exclusive Overlap 9.94e-01 8.91e-01 9.74e-01 9.98e-01 gwas Exclusive Overlap 9.46e-01 9.64e-01 8.04e-01 9.46e-01 Overlap Exclusives 9.25e-02 9.86e-02 2.22e-01 1.79e-02 Evaluating how well eaml genes are linked to gwas genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) eaml Exclusive gwas 0.59 0.41 0.56 0.53 2.50 gwas Exclusive eaml 0.52 1.00 1.08 0.83 0.68 eaml Exclusive gwas Exclusive 0.59 0.22 0.63 0.34 2.59 gwas Exclusive eaml Exclusive 0.52 1.19 0.90 0.76 0.60 eaml Exclusive Overlap 0.52 0.09 0.44 0.25 0.01 gwas Exclusive Overlap 0.48 0.16 0.01 0.01 -0.02 Overlap Exclusives 0.56 0.42 1.67 0.61 2.54 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) eaml Exclusive gwas 0.01 0.32 0.75 0.34 0.70 gwas Exclusive eaml 0.01 0.85 0.09 0.41 0.12 eaml Exclusive gwas Exclusive 0.01 0.19 0.81 0.22 0.78 gwas Exclusive eaml Exclusive 0.01 0.81 -0.08 0.29 -0.14 eaml Exclusive Overlap 0.00 -0.39 -0.17 -0.27 -0.23 gwas Exclusive Overlap 0.00 -0.20 -0.29 -0.39 -0.35 Overlap Exclusives 0.01 0.48 1.36 0.15 2.02 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes eaml Exclusive 101 101 gwas Exclusive 75 74 CASC16 Overlap 2 2