Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
epi	singleton	5.24e-01	9.49e-01	2.50e-01	8.02e-02
singleton	epi	2.20e-02	7.22e-01	6.83e-08	3.21e-01



Evaluating how well epi genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi	singleton	0.63	-0.94	-0.57	-1.17	2.34
singleton	epi	0.47	-0.27	-0.70	-0.36	-1.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi	singleton	0.00	-0.72	-0.62	-0.81	0.75
singleton	epi	0.01	-0.22	-0.76	-0.47	-1.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
epi	120	119	AC008695.1
singleton	21	21