Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet Exclusive	singleton	5.60e-01	3.63e-01	1.42e-08	1.39e-06
singleton Exclusive	wavelet	3.06e-02	1.06e-01	1.48e-20	5.89e-25
wavelet Exclusive	singleton Exclusive	6.80e-01	5.16e-01	2.42e-07	1.85e-05
singleton Exclusive	wavelet Exclusive	3.29e-02	1.30e-01	1.83e-20	8.95e-25
wavelet Exclusive	Overlap	4.12e-01	4.40e-01	4.00e-02	1.31e-01
singleton Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	5.04e-03	1.41e-02	1.50e-17	8.66e-30



Evaluating how well wavelet genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	singleton	0.80	1.65	1.24	2.00	4.98
singleton Exclusive	wavelet	0.72	-0.01	1.81	1.97	13.41
wavelet Exclusive	singleton Exclusive	0.80	1.92	1.17	1.86	4.38
singleton Exclusive	wavelet Exclusive	0.71	-0.09	1.42	1.88	10.86
wavelet Exclusive	Overlap	0.75	1.42	0.46	0.26	1.08
singleton Exclusive	Overlap	1.00	2.18	2.81	2.70	2.43
Overlap	Exclusives	0.72	0.54	1.30	0.53	12.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	singleton	0.00	-0.96	-3.19	1.00	4.21
singleton Exclusive	wavelet	0.03	1.05	3.70	4.76	14.01
wavelet Exclusive	singleton Exclusive	0.00	-0.85	-2.88	0.77	4.82
singleton Exclusive	wavelet Exclusive	0.03	0.13	1.65	3.56	12.97
wavelet Exclusive	Overlap	0.00	0.47	-0.09	-0.28	-0.15
singleton Exclusive	Overlap	0.17	505.97	406.99	443.96	157.32
Overlap	Exclusives	0.03	2.10	4.85	1.26	11.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet Exclusive	257	256	SOS 1
singleton Exclusive	19	19	
Overlap	2	2