Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet Exclusive	gwas	7.39e-01	6.74e-01	3.16e-06	1.63e-03
gwas Exclusive	wavelet	8.99e-02	2.22e-03	1.72e-12	1.12e-27
wavelet Exclusive	gwas Exclusive	8.14e-01	6.44e-01	4.12e-05	2.83e-03
gwas Exclusive	wavelet Exclusive	4.69e-02	3.14e-03	9.31e-11	1.77e-26
wavelet Exclusive	Overlap	1.88e-01	1.43e-01	7.92e-04	4.24e-03
gwas Exclusive	Overlap	9.28e-01	9.51e-01	4.07e-01	6.93e-02
Overlap	Exclusives	4.00e-04	2.10e-02	3.42e-56	2.16e-42



Evaluating how well wavelet genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	gwas	0.61	1.69	0.51	0.68	3.10
gwas Exclusive	wavelet	0.70	-0.09	2.24	1.60	11.58
wavelet Exclusive	gwas Exclusive	0.59	1.14	0.26	0.55	2.88
gwas Exclusive	wavelet Exclusive	0.70	-0.32	2.00	1.57	10.81
wavelet Exclusive	Overlap	0.90	1.55	2.32	2.06	3.06
gwas Exclusive	Overlap	0.72	0.07	0.16	0.28	1.98
Overlap	Exclusives	0.73	3.63	4.15	2.19	14.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	gwas	0.01	0.40	-1.25	0.63	3.49
gwas Exclusive	wavelet	0.02	-0.77	1.03	1.43	14.38
wavelet Exclusive	gwas Exclusive	0.01	0.10	-1.71	0.71	3.05
gwas Exclusive	wavelet Exclusive	0.02	-1.17	0.47	1.01	9.81
wavelet Exclusive	Overlap	0.00	0.61	0.76	1.55	3.64
gwas Exclusive	Overlap	0.01	38.07	50.21	36.18	31.92
Overlap	Exclusives	0.04	5.02	5.70	3.25	17.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet Exclusive	254	253	SOS 1
gwas Exclusive	72	71	CASC16
Overlap	5	5