Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavlet Exclusive	singleton	6.48e-01	6.03e-01	3.85e-08	1.25e-06
singleton Exclusive	wavlet	2.93e-02	7.41e-01	3.95e-14	1.02e-24
wavlet Exclusive	singleton Exclusive	7.86e-01	8.14e-01	4.15e-07	8.51e-06
singleton Exclusive	wavlet Exclusive	1.32e-02	8.38e-01	3.10e-13	1.89e-24
wavlet Exclusive	Overlap	6.10e-01	3.60e-01	7.68e-03	1.06e-01
singleton Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.96e-04
Overlap	Exclusives	2.24e-08	1.61e-03	1.93e-34	5.63e-37



Evaluating how well wavlet genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavlet Exclusive	singleton	0.80	1.41	0.92	1.82	4.71
singleton Exclusive	wavlet	0.71	-0.07	1.82	1.55	12.07
wavlet Exclusive	singleton Exclusive	0.79	1.37	0.87	1.66	4.28
singleton Exclusive	wavlet Exclusive	0.71	-0.52	1.11	1.68	12.18
wavlet Exclusive	Overlap	0.84	0.90	0.77	1.04	1.59
singleton Exclusive	Overlap	1.00	2.63	3.65	2.81	2.28
Overlap	Exclusives	0.74	1.11	1.99	1.38	13.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavlet Exclusive	singleton	0.00	-1.05	-1.57	1.09	4.32
singleton Exclusive	wavlet	0.02	0.25	1.81	3.02	12.98
wavlet Exclusive	singleton Exclusive	0.00	-1.17	-1.94	1.11	5.07
singleton Exclusive	wavlet Exclusive	0.02	-0.51	0.73	2.95	11.77
wavlet Exclusive	Overlap	0.00	0.10	-0.07	0.08	-0.10
singleton Exclusive	Overlap	0.03	43.60	591.49	57.60	26.99
Overlap	Exclusives	0.03	2.42	5.78	2.05	22.60

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavlet Exclusive	237	234	2021-09-09 00:00:00;SOS 1;ARL 11.00
singleton Exclusive	19	19	
Overlap	2	2