Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
epi	singleton	1.58e-01	7.71e-01	3.98e-02	2.97e-02
singleton	epi	5.47e-02	7.05e-01	4.39e-07	2.74e-01



Evaluating how well epi genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi	singleton	0.64	-0.92	-0.32	-1.16	2.27
singleton	epi	0.46	-0.78	-1.24	-1.10	-1.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi	singleton	0.00	-1.03	-0.98	-0.74	0.25
singleton	epi	0.01	-0.64	-1.39	-0.67	-1.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
epi	127	126	AC010255.3
singleton	21	21