Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mudiff09	singleton	1.38e-03	2.80e-04	1.40e-03	6.82e-08
singleton	mudiff09	8.34e-02	2.81e-01	1.36e-11	2.54e-01



Evaluating how well mudiff09 genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mudiff09	singleton	0.86	3.29	4.97	3.18	5.49
singleton	mudiff09	0.54	2.76	1.98	2.09	2.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mudiff09	singleton	0.01	5.00	12.11	5.74	6.35
singleton	mudiff09	0.01	8.30	3.32	2.74	4.82

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mudiff09	143	143	
singleton	21	21