Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) eaml singleton 1.78e-01 7.85e-01 5.22e-02 6.76e-03 singleton eaml 7.98e-01 7.38e-01 5.82e-08 2.13e-02 Evaluating how well eaml genes are linked to singleton genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) eaml singleton 0.68 -0.55 0.29 -0.60 2.86 singleton eaml 0.46 0.88 -0.17 0.20 -2.07 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) eaml singleton 0.00 -1.07 -0.77 -1.25 0.22 singleton eaml 0.01 -0.07 -0.82 -0.44 -1.57 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes eaml 219 216 BX276092.9;PNMA6F;AC091959.3 singleton 21 21