Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet Exclusive	singleton	7.25e-01	7.88e-01	5.36e-05	4.58e-03
singleton Exclusive	wavelet	2.00e-05	8.29e-01	3.97e-12	1.16e-19
wavelet Exclusive	singleton Exclusive	8.74e-01	7.33e-01	3.79e-04	7.32e-03
singleton Exclusive	wavelet Exclusive	4.06e-06	8.85e-01	2.34e-10	8.63e-19
wavelet Exclusive	Overlap	1.58e-01	8.91e-01	1.98e-02	1.19e-01
singleton Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.95e-07	8.82e-09	1.35e-39	3.15e-31



Evaluating how well wavelet genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	singleton	0.74	-0.56	-0.86	0.83	3.81
singleton Exclusive	wavelet	0.70	-1.99	0.18	0.81	10.69
wavelet Exclusive	singleton Exclusive	0.73	-0.57	-1.13	0.73	3.54
singleton Exclusive	wavelet Exclusive	0.70	-2.42	0.02	0.69	9.66
wavelet Exclusive	Overlap	0.91	1.10	0.68	0.85	1.55
singleton Exclusive	Overlap	1.00	2.33	1.95	2.14	1.71
Overlap	Exclusives	0.76	1.05	5.69	1.72	12.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	singleton	0.00	-1.03	-6.57	1.22	3.95
singleton Exclusive	wavelet	0.02	-0.93	0.66	2.48	7.63
wavelet Exclusive	singleton Exclusive	0.00	-1.22	-6.84	1.05	1.26
singleton Exclusive	wavelet Exclusive	0.02	-1.60	-0.06	1.67	6.86
wavelet Exclusive	Overlap	0.00	0.90	-0.00	0.08	0.20
singleton Exclusive	Overlap	0.06	433.05	233.04	330.56	187.74
Overlap	Exclusives	0.03	2.27	12.68	3.29	19.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet Exclusive	194	194	
singleton Exclusive	20	20	
Overlap	1	1