Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
epi	singleton	3.56e-02	4.39e-01	5.67e-02	1.79e-02
singleton	epi	2.65e-01	7.10e-01	6.57e-05	9.24e-01



Evaluating how well epi genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi	singleton	0.63	-1.21	-0.41	-0.92	1.93
singleton	epi	0.49	-0.09	-1.43	-0.98	-0.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi	singleton	0.00	-1.13	-0.81	-0.82	0.35
singleton	epi	0.01	-0.31	-1.35	-1.08	-0.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
epi	110	109	PNMA6F
singleton	21	21