Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
eaml	adisamel	4.31e-02	7.74e-02	7.99e-03	8.71e-01
adisamel	eaml	3.98e-03	4.57e-01	5.45e-06	3.64e-02



Evaluating how well eaml genes are linked to adisamel genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml	adisamel	0.51	-1.71	-2.54	-2.03	0.22
adisamel	eaml	0.44	-0.49	-1.90	-0.86	-2.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml	adisamel	0.00	-0.74	-2.05	-1.45	-0.23
adisamel	eaml	0.01	-0.95	-1.57	-1.04	-2.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
eaml	219	216	AC091959.3;PNMA6F;BX276092.9
adisamel	14	14