Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
epi	adesmael	4.87e-02	2.02e-01	1.88e-01	3.39e-01
adesmael	epi	1.62e-01	5.71e-01	2.27e-03	6.91e-01



Evaluating how well epi genes are linked to adesmael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi	adesmael	0.59	-1.21	-1.20	-0.80	1.15
adesmael	epi	0.50	0.67	-0.91	-0.77	-0.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi	adesmael	0.00	-0.97	-0.60	-0.59	0.09
adesmael	epi	0.01	0.11	-1.09	-0.50	-0.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
epi	110	109	PNMA6F
adesmael	14	14