Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
eaml Exclusive	lbdgs	5.92e-01	5.21e-01	7.07e-01	2.90e-02
lbdgs Exclusive	eaml	9.84e-03	4.26e-01	7.31e-30	1.22e-02
eaml Exclusive	lbdgs Exclusive	6.01e-01	9.58e-01	5.78e-01	8.07e-02
lbdgs Exclusive	eaml Exclusive	1.52e-02	5.85e-01	6.61e-29	1.29e-02
eaml Exclusive	Overlap	7.92e-02	1.98e-02	2.97e-01	7.92e-02
lbdgs Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	5.11e-02	6.25e-01	7.29e-32	5.59e-02



Evaluating how well eaml genes are linked to lbdgs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml Exclusive	lbdgs	0.77	-0.02	0.28	-0.22	2.33
lbdgs Exclusive	eaml	0.46	1.39	0.37	0.32	-1.83
eaml Exclusive	lbdgs Exclusive	0.73	-0.30	0.41	-0.33	2.05
lbdgs Exclusive	eaml Exclusive	0.46	1.02	0.13	0.02	-2.05
eaml Exclusive	Overlap	0.98	0.98	170462470212057.00	0.63	1.43
lbdgs Exclusive	Overlap	0.99	2.93	358648434489119.00	1.98	1.74
Overlap	Exclusives	0.47	-129348987220157.00	0.46	-0.14	-1.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml Exclusive	lbdgs	0.00	-0.01	1.47	-0.73	0.50
lbdgs Exclusive	eaml	0.01	0.38	-0.04	0.09	-1.00
eaml Exclusive	lbdgs Exclusive	0.00	-0.59	0.30	-1.01	1.00
lbdgs Exclusive	eaml Exclusive	0.01	0.04	-0.30	-0.19	-1.08
eaml Exclusive	Overlap	0.00	0.69	12640017707141504.00	-0.10	0.92
lbdgs Exclusive	Overlap	0.00	17.05	inf	15.72	8.44
Overlap	Exclusives	0.02	inf	6.84	1.56	5.14

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
eaml Exclusive	218	215	AC091959.3;BX276092.9;PNMA6F
lbdgs Exclusive	5	5	
Overlap	1	1