Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet Exclusive	lbdgs	5.56e-01	4.31e-01	3.78e-04	7.60e-04
lbdgs Exclusive	wavelet	1.25e-02	3.06e-02	2.44e-48	7.67e-26
wavelet Exclusive	lbdgs Exclusive	9.05e-01	9.12e-01	1.49e-02	3.60e-02
lbdgs Exclusive	wavelet Exclusive	8.48e-03	3.63e-02	6.44e-49	4.54e-25
wavelet Exclusive	Overlap	5.17e-01	5.17e-01	5.91e-04	4.00e-02
lbdgs Exclusive	Overlap	9.85e-04	9.85e-05	1.48e-03	9.85e-04
Overlap	Exclusives	4.30e-01	9.40e-04	2.70e-51	1.75e-25



Evaluating how well wavelet genes are linked to lbdgs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	lbdgs	0.82	1.06	0.47	0.59	2.82
lbdgs Exclusive	wavelet	0.72	-3.38	1.35	0.57	11.30
wavelet Exclusive	lbdgs Exclusive	0.75	0.64	0.03	0.18	1.59
lbdgs Exclusive	wavelet Exclusive	0.72	-4.26	1.24	0.43	10.33
wavelet Exclusive	Overlap	0.95	1.20	0.51	0.97	1.99
lbdgs Exclusive	Overlap	0.99	4.43	2.86	1.95	2.44
Overlap	Exclusives	0.73	0.10	2.82	0.91	10.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	lbdgs	0.00	-0.75	-57.79	1.23	2.13
lbdgs Exclusive	wavelet	0.02	-1.16	1.71	0.71	10.19
wavelet Exclusive	lbdgs Exclusive	0.00	-1.15	-126.96	0.05	1.33
lbdgs Exclusive	wavelet Exclusive	0.02	-1.88	1.13	0.35	8.44
wavelet Exclusive	Overlap	0.00	3.10	-11.65	2.98	5.71
lbdgs Exclusive	Overlap	0.01	30.17	74.18	29.05	1.19
Overlap	Exclusives	0.02	0.56	5.64	1.57	10.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet Exclusive	193	193	
lbdgs Exclusive	4	4	
Overlap	2	2