Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
eaml Exclusive	ADgs	2.08e-01	2.68e-01	4.72e-02	3.05e-01
ADgs Exclusive	eaml	1.26e-02	3.56e-01	8.59e-01	2.75e-02
eaml Exclusive	ADgs Exclusive	1.29e-01	1.93e-01	6.04e-02	4.04e-01
ADgs Exclusive	eaml Exclusive	1.53e-02	3.52e-01	5.62e-01	1.79e-02
eaml Exclusive	Overlap	5.74e-01	5.17e-01	5.92e-01	6.10e-01
ADgs Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.96e-04
Overlap	Exclusives	3.07e-02	9.87e-02	3.99e-32	1.69e-01



Evaluating how well eaml genes are linked to ADgs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml Exclusive	ADgs	0.54	-1.10	-1.62	-1.56	0.81
ADgs Exclusive	eaml	0.44	-0.95	-1.68	-0.81	-3.00
eaml Exclusive	ADgs Exclusive	0.52	-0.98	-1.40	-1.47	0.51
ADgs Exclusive	eaml Exclusive	0.44	-0.89	-1.48	-0.72	-3.29
eaml Exclusive	Overlap	0.71	-1.06	-0.61	-1.21	0.81
ADgs Exclusive	Overlap	1.00	1.96	1.49	2.65	2.27
Overlap	Exclusives	0.50	1.36	2.53	0.74	0.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml Exclusive	ADgs	0.00	-0.67	-0.87	-0.98	-0.16
ADgs Exclusive	eaml	0.01	-0.17	-0.55	-0.30	-1.32
eaml Exclusive	ADgs Exclusive	0.00	-0.66	-0.84	-0.66	-0.18
ADgs Exclusive	eaml Exclusive	0.01	-0.81	-1.28	-0.73	-1.68
eaml Exclusive	Overlap	0.00	0.23	2.59	-0.38	-0.03
ADgs Exclusive	Overlap	0.03	38.02	121.81	104.48	21.19
Overlap	Exclusives	0.03	18.48	25.65	6.36	15.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
eaml Exclusive	217	214	BX276092.9;PNMA6F;AC091959.3
ADgs Exclusive	23	22	HLA -DRB1
Overlap	2	2