Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GS_GWAS Exclusive	degenerate	1.37e-02	5.49e-01	5.63e-02	1.94e-01
degenerate Exclusive	GS_GWAS	3.89e-01	8.25e-01	8.34e-01	8.91e-02
GS_GWAS Exclusive	degenerate Exclusive	1.10e-02	5.85e-01	7.70e-02	4.11e-01
degenerate Exclusive	GS_GWAS Exclusive	4.05e-01	8.66e-01	7.75e-01	9.72e-02
GS_GWAS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
degenerate Exclusive	Overlap	3.19e-01	4.31e-01	4.59e-01	4.03e-01
Overlap	Exclusives	4.51e-02	2.11e-02	1.08e-07	5.98e-03



Evaluating how well GS_GWAS genes are linked to degenerate genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS_GWAS Exclusive	degenerate	0.53	0.01	-0.25	0.29	1.33
degenerate Exclusive	GS_GWAS	0.62	-0.99	-0.28	-0.05	2.03
GS_GWAS Exclusive	degenerate Exclusive	0.52	-0.41	-0.39	0.03	0.97
degenerate Exclusive	GS_GWAS Exclusive	0.64	-0.75	0.02	0.24	2.19
GS_GWAS Exclusive	Overlap	1.00	2.38	2.52	2.66	2.32
degenerate Exclusive	Overlap	0.40	-0.84	-0.84	-0.95	-0.64
Overlap	Exclusives	0.58	1.65	2.38	1.64	3.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS_GWAS Exclusive	degenerate	0.01	3.01	1.43	3.00	5.20
degenerate Exclusive	GS_GWAS	0.00	-0.45	0.43	0.20	1.03
GS_GWAS Exclusive	degenerate Exclusive	0.01	-0.37	-0.32	0.27	0.31
degenerate Exclusive	GS_GWAS Exclusive	0.00	-0.35	0.66	0.26	2.17
GS_GWAS Exclusive	Overlap	0.15	254.78	521.14	310.34	119.99
degenerate Exclusive	Overlap	0.00	-0.42	-0.53	-0.31	-0.25
Overlap	Exclusives	0.03	23.27	27.18	18.76	24.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GS_GWAS Exclusive	23	23	
degenerate Exclusive	139	138	AC004997.1
Overlap	2	2