Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GS_GWAS Exclusive	Non degenerate	1.24e-01	3.88e-01	1.24e-02	2.83e-01
Non degenerate Exclusive	GS_GWAS	1.77e-06	1.22e-05	2.23e-06	2.82e-08
GS_GWAS Exclusive	Non degenerate Exclusive	4.11e-01	3.93e-01	6.28e-03	4.89e-01
Non degenerate Exclusive	GS_GWAS Exclusive	4.13e-06	6.04e-06	2.59e-06	2.13e-07
GS_GWAS Exclusive	Overlap	4.47e-11	2.42e-06	9.39e-10	8.67e-08
Non degenerate Exclusive	Overlap	1.49e-01	3.81e-01	1.19e-01	4.42e-03
Overlap	Exclusives	7.66e-02	6.14e-02	2.37e-12	3.42e-02



Evaluating how well GS_GWAS genes are linked to Non degenerate genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS_GWAS Exclusive	Non degenerate	0.54	1.90	1.56	1.58	1.73
Non degenerate Exclusive	GS_GWAS	0.84	3.70	4.86	3.45	5.48
GS_GWAS Exclusive	Non degenerate Exclusive	0.52	1.73	1.32	1.31	0.92
Non degenerate Exclusive	GS_GWAS Exclusive	0.83	3.20	4.93	3.37	4.68
GS_GWAS Exclusive	Overlap	0.99	3.87	3.48	2.89	3.89
Non degenerate Exclusive	Overlap	0.87	1.89	1.63	2.32	2.71
Overlap	Exclusives	0.56	1.44	3.17	2.50	3.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS_GWAS Exclusive	Non degenerate	0.02	15.83	14.53	10.89	13.85
Non degenerate Exclusive	GS_GWAS	0.02	21.21	30.50	23.16	38.46
GS_GWAS Exclusive	Non degenerate Exclusive	0.02	7.41	5.20	8.97	6.35
Non degenerate Exclusive	GS_GWAS Exclusive	0.01	21.53	42.32	27.17	29.06
GS_GWAS Exclusive	Overlap	0.06	238.13	107.44	156.13	22.86
Non degenerate Exclusive	Overlap	0.00	2.96	1.27	4.64	2.88
Overlap	Exclusives	0.04	29.04	54.67	38.22	44.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GS_GWAS Exclusive	20	20	
Non degenerate Exclusive	171	168	PRAMEF11;AC004754.1;RFPL2
Overlap	5	5