Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GS_rare Exclusive	Degenerate	1.07e-01	6.48e-01	9.88e-02	4.02e-01
Degenerate Exclusive	GS_rare	4.52e-01	8.02e-01	8.76e-01	1.80e-01
GS_rare Exclusive	Degenerate Exclusive	8.69e-02	4.17e-01	1.62e-01	4.33e-01
Degenerate Exclusive	GS_rare Exclusive	6.98e-01	9.51e-01	6.05e-01	8.61e-02
GS_rare Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Degenerate Exclusive	Overlap	3.86e-01	5.37e-01	4.12e-01	5.37e-01
Overlap	Exclusives	1.80e-02	1.33e-01	9.72e-08	8.54e-02



Evaluating how well GS_rare genes are linked to Degenerate genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS_rare Exclusive	Degenerate	0.54	0.19	0.39	0.25	1.37
Degenerate Exclusive	GS_rare	0.60	-0.60	-0.12	-0.23	1.42
GS_rare Exclusive	Degenerate Exclusive	0.53	-0.12	-0.25	0.22	1.22
Degenerate Exclusive	GS_rare Exclusive	0.62	-0.42	0.19	0.25	1.88
GS_rare Exclusive	Overlap	1.00	3.35	2.22	2.55	2.45
Degenerate Exclusive	Overlap	0.40	-0.78	-0.79	-1.04	-0.42
Overlap	Exclusives	0.56	1.11	1.40	1.21	2.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS_rare Exclusive	Degenerate	0.01	3.40	3.54	1.72	2.96
Degenerate Exclusive	GS_rare	0.00	-0.49	-0.09	-0.28	0.19
GS_rare Exclusive	Degenerate Exclusive	0.01	0.20	-0.27	0.05	1.08
Degenerate Exclusive	GS_rare Exclusive	0.00	-0.38	0.06	-0.09	0.59
GS_rare Exclusive	Overlap	0.15	1167.23	778.57	167.78	486.34
Degenerate Exclusive	Overlap	0.00	-0.53	-0.56	-0.51	-0.33
Overlap	Exclusives	0.02	14.51	14.15	15.18	19.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GS_rare Exclusive	16	16	
Degenerate Exclusive	139	138	AC004997.1
Overlap	2	2