Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) mudiff gp2m 5.49e-01 5.56e-01 5.49e-01 3.58e-01 gp2m mudiff 7.77e-01 8.48e-01 1.94e-08 6.33e-01 Evaluating how well mudiff genes are linked to gp2m genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) mudiff gp2m 0.69 0.20 0.37 0.39 1.73 gp2m mudiff 0.50 0.49 0.16 0.31 0.32 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) mudiff gp2m 0.00 1.72 0.90 1.91 0.27 gp2m mudiff 0.01 0.52 0.69 0.66 0.60 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes mudiff 159 159 gp2m 6 6