Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mudiff	gp2m	5.49e-01	5.56e-01	5.49e-01	3.58e-01
gp2m	mudiff	7.77e-01	8.48e-01	1.94e-08	6.33e-01



Evaluating how well mudiff genes are linked to gp2m genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mudiff	gp2m	0.69	0.20	0.37	0.39	1.73
gp2m	mudiff	0.50	0.49	0.16	0.31	0.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mudiff	gp2m	0.00	1.72	0.90	1.91	0.27
gp2m	mudiff	0.01	0.52	0.69	0.66	0.60

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mudiff	159	159	
gp2m	6	6