Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
epi	gp2	5.82e-01	2.54e-01	6.61e-01	2.70e-03
gp2	epi	4.09e-01	3.86e-01	1.40e-14	8.78e-01



Evaluating how well epi genes are linked to gp2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi	gp2	0.78	1.24	1.97	1.30	2.92
gp2	epi	0.50	0.95	0.72	0.76	0.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi	gp2	0.00	0.65	-0.05	0.39	1.28
gp2	epi	0.01	1.88	1.57	1.39	0.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
epi	127	126	AC010255.3
gp2	10	9	GBNMP