Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
FullCohort_BRCA_AllCoreGenes Exclusive	BRCA-somatic	7.83e-03	8.37e-03	1.52e-13	1.47e-21
BRCA-somatic Exclusive	FullCohort_BRCA_AllCoreGenes	1.19e-03	4.97e-02	5.03e-20	4.73e-10
FullCohort_BRCA_AllCoreGenes Exclusive	BRCA-somatic Exclusive	5.41e-02	2.52e-02	7.81e-11	1.23e-18
BRCA-somatic Exclusive	FullCohort_BRCA_AllCoreGenes Exclusive	4.49e-03	6.62e-02	6.76e-20	1.75e-09
FullCohort_BRCA_AllCoreGenes Exclusive	Overlap	5.77e-03	3.72e-02	8.71e-06	4.22e-04
BRCA-somatic Exclusive	Overlap	4.36e-07	2.44e-04	4.36e-07	4.36e-06
Overlap	Exclusives	2.80e-21	1.46e-17	1.76e-49	1.22e-30



Evaluating how well FullCohort_BRCA_AllCoreGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FullCohort_BRCA_AllCoreGenes Exclusive	BRCA-somatic	0.91	1.34	3.89	2.57	8.19
BRCA-somatic Exclusive	FullCohort_BRCA_AllCoreGenes	0.69	-0.22	2.13	1.60	8.35
FullCohort_BRCA_AllCoreGenes Exclusive	BRCA-somatic Exclusive	0.91	1.06	3.35	2.23	8.72
BRCA-somatic Exclusive	FullCohort_BRCA_AllCoreGenes Exclusive	0.69	-0.31	2.54	1.88	7.89
FullCohort_BRCA_AllCoreGenes Exclusive	Overlap	0.98	1.42	2.71	1.83	3.06
BRCA-somatic Exclusive	Overlap	1.00	1.41	2.54	2.14	3.00
Overlap	Exclusives	0.81	2.88	8.02	3.13	12.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FullCohort_BRCA_AllCoreGenes Exclusive	BRCA-somatic	0.02	-1.70	5.54	2.83	29.22
BRCA-somatic Exclusive	FullCohort_BRCA_AllCoreGenes	0.02	0.06	5.70	5.18	16.58
FullCohort_BRCA_AllCoreGenes Exclusive	BRCA-somatic Exclusive	0.01	-1.97	2.21	1.06	9.34
BRCA-somatic Exclusive	FullCohort_BRCA_AllCoreGenes Exclusive	0.02	-0.26	4.10	5.56	8.62
FullCohort_BRCA_AllCoreGenes Exclusive	Overlap	0.02	8.13	53.96	21.61	81.68
BRCA-somatic Exclusive	Overlap	0.02	1.98	16.68	32.31	24.07
Overlap	Exclusives	0.07	16.64	58.13	20.82	55.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
FullCohort_BRCA_AllCoreGenes Exclusive	124	124	
BRCA-somatic Exclusive	34	34	
Overlap	3	3