Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
FullCohort_BRCA_AllCoreGenes Exclusive	BRCA-gwas	1.27e-02	6.84e-01	7.64e-06	3.78e-06
BRCA-gwas Exclusive	FullCohort_BRCA_AllCoreGenes	3.40e-02	4.13e-02	4.06e-14	4.90e-10
FullCohort_BRCA_AllCoreGenes Exclusive	BRCA-gwas Exclusive	7.09e-03	6.11e-01	5.25e-05	2.53e-05
BRCA-gwas Exclusive	FullCohort_BRCA_AllCoreGenes Exclusive	4.11e-02	4.03e-02	1.00e-12	3.06e-09
FullCohort_BRCA_AllCoreGenes Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	4.35e-06
BRCA-gwas Exclusive	Overlap	3.87e-04	1.40e-03	9.14e-09	1.83e-06
Overlap	Exclusives	1.13e-11	2.38e-08	6.23e-47	3.00e-28



Evaluating how well FullCohort_BRCA_AllCoreGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FullCohort_BRCA_AllCoreGenes Exclusive	BRCA-gwas	0.63	0.38	1.22	1.72	6.32
BRCA-gwas Exclusive	FullCohort_BRCA_AllCoreGenes	0.67	-0.58	0.71	1.05	6.11
FullCohort_BRCA_AllCoreGenes Exclusive	BRCA-gwas Exclusive	0.62	0.08	1.29	1.71	6.06
BRCA-gwas Exclusive	FullCohort_BRCA_AllCoreGenes Exclusive	0.66	-0.59	0.42	0.87	6.19
FullCohort_BRCA_AllCoreGenes Exclusive	Overlap	0.98	2.03	2.85	2.28	3.33
BRCA-gwas Exclusive	Overlap	0.99	1.68	2.17	2.37	3.40
Overlap	Exclusives	0.71	4.98	7.87	3.05	13.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FullCohort_BRCA_AllCoreGenes Exclusive	BRCA-gwas	0.02	-0.87	2.02	2.04	5.56
BRCA-gwas Exclusive	FullCohort_BRCA_AllCoreGenes	0.02	1.42	8.31	3.86	16.25
FullCohort_BRCA_AllCoreGenes Exclusive	BRCA-gwas Exclusive	0.01	-1.53	0.31	0.98	6.35
BRCA-gwas Exclusive	FullCohort_BRCA_AllCoreGenes Exclusive	0.02	1.11	5.19	3.67	13.19
FullCohort_BRCA_AllCoreGenes Exclusive	Overlap	0.02	15.22	52.98	36.22	56.09
BRCA-gwas Exclusive	Overlap	0.02	3.90	32.89	30.54	9.69
Overlap	Exclusives	0.06	15.01	34.11	13.39	50.90

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
FullCohort_BRCA_AllCoreGenes Exclusive	123	123	
BRCA-gwas Exclusive	169	169	
Overlap	4	4